{"id":118,"date":"2025-11-19T04:43:29","date_gmt":"2025-11-19T04:43:29","guid":{"rendered":"https:\/\/research.karkinos.in\/?p=118"},"modified":"2025-11-19T04:48:28","modified_gmt":"2025-11-19T04:48:28","slug":"elementor-118","status":"publish","type":"post","link":"https:\/\/research.karkinos.in\/?p=118","title":{"rendered":"Germline testing in Breast Cancer impacts patients"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"118\" class=\"elementor elementor-118\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f10d57e e-flex e-con-boxed e-con e-parent\" data-id=\"f10d57e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-a8a49a6 e-con-full e-flex e-con e-child\" data-id=\"a8a49a6\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-34d9289 elementor-widget elementor-widget-image\" data-id=\"34d9289\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"944\" height=\"944\" src=\"https:\/\/research.karkinos.in\/wp-content\/uploads\/2025\/11\/SocialMedia-2.png\" class=\"attachment-large size-large wp-image-83\" alt=\"\" srcset=\"https:\/\/research.karkinos.in\/wp-content\/uploads\/2025\/11\/SocialMedia-2.png 944w, https:\/\/research.karkinos.in\/wp-content\/uploads\/2025\/11\/SocialMedia-2-300x300.png 300w, https:\/\/research.karkinos.in\/wp-content\/uploads\/2025\/11\/SocialMedia-2-150x150.png 150w, https:\/\/research.karkinos.in\/wp-content\/uploads\/2025\/11\/SocialMedia-2-768x768.png 768w\" sizes=\"(max-width: 944px) 100vw, 944px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b16551d e-con-full e-flex e-con e-child\" data-id=\"b16551d\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d6f6c15 elementor-widget elementor-widget-text-editor\" data-id=\"d6f6c15\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>In one of the largest Indian study which included germline sequences of 479 unselected Indian patients with\u00a0<span style=\"font-size: 1rem;\">breast cancer<\/span><span style=\"font-size: 1rem;\">\u00a0<\/span><span style=\"font-size: 1rem;\">. Pathogenic or likely pathogenic variants were identified in 24.6% of the cohort,\u00a0including 8.35% in BRCA1\/2. Notably, 67% of these findings were in non-BRCA genes,\u00a0including HRR and tumor suppressor genes, which would be missed by BRCA-only testing. Beyond cancer risk, medically\u00a0actionable secondary findings were detected in 21.7% of individuals, with variants in non-oncology genes listed in ACMG SF v3.2. This study suggests germline testing enables more accurate risk assessment, personalized\u00a0therapeutic decisions, and the implementation of preventive interventions in genetically diverse\u00a0populations.<\/span><\/p><p>Read the publication online<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>In one of the largest Indian study which included germline sequences of 479 unselected Indian patients with\u00a0breast cancer\u00a0. Pathogenic or likely pathogenic variants were identified in 24.6% of the cohort,\u00a0including 8.35% in BRCA1\/2. Notably, 67% of these findings were in non-BRCA genes,\u00a0including HRR and tumor suppressor genes, which would be missed by BRCA-only testing. Beyond [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-118","post","type-post","status-publish","format-standard","hentry","category-uncategorized","wpbf-post"],"_links":{"self":[{"href":"https:\/\/research.karkinos.in\/index.php?rest_route=\/wp\/v2\/posts\/118","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/research.karkinos.in\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/research.karkinos.in\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/research.karkinos.in\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/research.karkinos.in\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=118"}],"version-history":[{"count":5,"href":"https:\/\/research.karkinos.in\/index.php?rest_route=\/wp\/v2\/posts\/118\/revisions"}],"predecessor-version":[{"id":126,"href":"https:\/\/research.karkinos.in\/index.php?rest_route=\/wp\/v2\/posts\/118\/revisions\/126"}],"wp:attachment":[{"href":"https:\/\/research.karkinos.in\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=118"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/research.karkinos.in\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=118"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/research.karkinos.in\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=118"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}